Abstract: This paper deals with two parabolic initial-boundary value problems in multidimensional domain. The first problem describes the situation where the spherical medium is static and the nonlinear reaction takes place only at a single point. We show that under some conditions, the solution blows up in finite time and the blow-up set is the whole spherical medium. When the spherical medium is allowed to move in a special space, we investigate another parabolic initial-boundary value problem. It is proved that the blow-up can be avoided if the acceleration of the motion satisfies certain conditions. 

Key words: moving , medium, blow-up, parabolic , problem