This paper investigates the existence of positive solutions for a fourth-order p-Laplacian nonlinear equation. We show that, under suitable conditions, there exists a positive number λ~*such that the above problem has at least two positive solutions for 0 < λ < λ~* , at least one positive solution for λ = λ~* and no solution forλ > λ~* by using the upper and lower solutions method and fixed point theory.