Stability and Hopf Bifurcation of a Virus Infection Model with a Delayed CTL Immune Response

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  • 1. College of Science, China University of Petroleum2. Institute of Applied Mathematics, Shijiazhuang Mechanical Engineering College
LI Xiao-tong(1964-), female, native of Zhangjiakou, Hebei, an associate professor of China University of Petroleum, M.S.D., engages in applied statistics and biomathematics.

Received date: 2013-11-26

  Online published: 2020-11-30

Supported by

Supported by the NNSF of China(11371368,11071254); Supported by the NSF of Hebei Province(A2014506015); Supported by the NSF for Young Scientists of Hebei Province(A2013506012);

Abstract

In this paper, a virus infection model with standard incidence rate and delayed CTL immune response is investigated. By analyzing corresponding characteristic equations,the local stability of each of feasible equilibria and the existence of Hopf bifurcations at the CTL-activated infection equilibrium are established, respectively. By means of comparison arguments, it is verified that the infection-free equilibrium is globally asymptotically stable if the basic reproduction ratio is less than unity. By using suitable Lyapunov functional and LaSalle’s invariance principle, it is shown that the CTL-inactivated infection equilibrium of the system is globally asymptotically stable if the immune response reproduction ratio is less than unity and the basic reproduction ratio is greater than unity. Numerical simulations are carried out to illustrate the theoretical result. 

Cite this article

LI Xiao-tong, TIAN Xiao-hong, XU Rui . Stability and Hopf Bifurcation of a Virus Infection Model with a Delayed CTL Immune Response[J]. Chinese Quarterly Journal of Mathematics, 2014 , 29(3) : 426 -437 . DOI: 10.13371/j.cnki.chin.q.j.m.2014.03.013

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