Some related problems of two n-dimensional simplices which are on an（n- 1）-dimensional hypersphere are investigated and a sine theorem of the k-dimensional mixed vertex angles which are defined in this paper is given. This result is a generalization of the sine theorem established. By using the generalized sine theorem, we present some new interesting geometric inequalities involving the k-dimensional vertex angles of each n-simplex and the k-dimensional mixed vertex angle of two n-simplices. These results can improve some recent results.